In this project we
develop new methods for the fast and reliable analysis of
extracellular data. We currently focus on the detection and
classification of action potentials in voltage traces which are
recorded simultaneously, for example, using multi-electrode and
multi-tetrode arrays. Our approach makes use of linear filters to find
a new representation of the data and to optimally enhance the
signal-to-noise ratio, makes use of source separation techniques to
decorrelate filter outputs. The developed methods are able to separate
overlapping spikes and can adapt to non-stationary data. Therefore,
they are well suited for acute recordings, where they allow for
on-line spike-sorting and -analysis. Together with Dr. M. Munk (MPI
for Biological Cybernetics) our methods are currently being evaluated
on data recorded from awake behaving monkeys during visual working
memory tasks. Current collaboration partners include but are not
limited to the University of Freiburg, the University of Oslo, the Max
Planck Institute for Biological Cybernetics (Tübingen), Thomas
RECORDING GmbH (Gießen) and the German Neuroscience Node (GNode).
Acknowledgements: Research is funded by BMBF (via the
Bernstein Center and a Bernstein Collaboration) and the Technische
Onken, A., Dragoi, V. and Obermayer, K.
(2012). A Maximum Entropy Test for Evaluating Higher-Order
Correlations in Spike Counts .
PLoS Computational Biology, 8
Franke, F., Natora, M., Meier, P., Hagen, E.,
Pettersen, K., Linden, H., Einevoll, G. and Obermayer, K. (2010).
An Automated Online Positioning System and Simulation Environment for
Multi-Electrodes in Extracellular Recordings . Proceedings of
32nd Annual International Conference of the IEEE EMBS, 593 –
Franke, F., Natora, M., Boucsein, C., Munk,
M. and Obermayer, K.
(2010). An Online Spike Detection and Spike Classification Algorithm
Capable of Instantaneous Resolution of Overlapping Spikes .
Journal of Computional Neuroscience, 127 – 148.
Vollgraf, R., Munk, M. and Obermayer, K.
(2005). Spike Sorting of Multi-Site Electrode Recordings .
Network - Computation in Neural Systems, 16, 85 – 113.