direkt zum Inhalt springen

direkt zum Hauptnavigationsmenü

Sie sind hier

TU Berlin

Page Content

All Publications

Development and Regeneration of the Retinotectal Map in Goldfish: A Computational Study
Citation key Weber1997
Author Weber, C. and Ritter, H. and Cowan, J. and Obermayer, K.
Pages 1603 – 1623
Year 1997
DOI 10.1098/rstb.1997.0144
Journal Philosophical Transaction of the Royal Society B
Volume 352
Abstract We present a simple computational model to study the in terplay of activity dependent and intrinsic processes thought to be involved in the formation of topographic neural projections. Our model consists of two input layers which project to one target layer. The connections between layers are described by a set of synaptic weights. These weights develop according to three interacting developmental rules: (i) an in trinsic fiber-target interaction which generates chemospecific adhesion between afferent fibers and target cells, (ii) an in trinsic fiber-fiber interaction which generates mutual selective adhesion between the afferent fibers and (iii) an activity-dependent fiber-fiber interaction which implements Hebbian learning. Additionally, constraints are imposed to keep synaptic weights finite. The model is applied to a set of eleven experiments on the regeneration of the retinotectal projection in goldfish. We find that the model is able to reproduce the outcome of an unprecedented range of experiments with the same set of model parameters, including details of the size of receptive and projective fields. We expect this mathematical framework to be a useful tool for the analysis of developmental processes in general.
Bibtex Type of Publication Selected:development
Link to publication Link to original publication Download Bibtex entry

Zusatzinformationen / Extras

Quick Access:

Schnellnavigation zur Seite über Nummerneingabe

Auxiliary Functions