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Synergistic Effects of the Dopaminergic and Glutamatergic System on Hippocampal Volume in Alcohol-Dependent Patients
Citation key Puls2008
Author Puls, I. and Mohr, J. and Wrase, J. and Priller, J. and Behr, J. and Kitzrow, W. and Makris, N. and Breiter, H. and Obermayer, K. and Heinz, A.
Pages 126 - 136
Year 2008
DOI doi:10.1016/j.biopsycho.2008.03.001
Journal Biological Psychology
Volume 79
Number 1
Publisher Elsevier
Abstract Several genes of the dopaminergic and glutamatergic neurotransmitter systems have been found to be associated with alcohol disease and related intermediate phenotypes. Here, we evaluated genetic variants of the catechol-O-methyltransferase and the metabotropic glutamate receptor 3 gene in alcohol-dependent patients and their association with volumetric measurements of brain structures. By combined analysis of imaging data and genotyping results, large numbers of variables are produced that overstrain conventional statistical methods based on tests for group differences. Limitations in assessment of epistatic effects and multiple testing problems are encountered. Therefore, we introduce a novel method for detecting associations between a set of genetic markers and phenotypical measurements based on machine learning techniques. Hippocampal volume was found to be associated with epistatic effects of the COMT-mGluR3 genes in alcohol-dependent patients but not in controls. These data are in line with prior studies supporting a role for dopamine-glutamate-interaction in modulation of alcohol disease.
Bibtex Type of Publication Selected:multimodal
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