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Simulation of Scanning Laser Techniques for Optical Imaging of Blood-Related Intrinsic Signals
Citation key Stetter1999a
Author Stetter, M. and Obermayer, K.
Pages 58 – 70
Year 1999
DOI 10.1364/JOSAA.16.000058
Journal Journal of the Optical Society of America
Volume 16
Number 1
Publisher Optical Society of America
Abstract Optical Imaging of intrinsic signals detects neural activation patterns by taking video images of the local activity-related changes in the light intensity reflected from neural tissue (intrinsic signals). At red light (605nm), these signals are mainly caused by local variations of the tissue absorption following deoxygenation of blood. In this work, we characterize the image generation process during Optical Imaging by Monte Carlo simulations of light propagation through a homogeneous model tissue equipped with a local absorber. Conventional video-imaging and Scanning Laser imaging are compared to each other. We find that, compared to video imaging, Scanning Laser techniques drastically increase both the contrast and the lateral resolution of optical recordings. Also, the maximum depth up to which the signals can be detected, is increased by roughly a factor of 2 using Scanning Laser Optical Imaging. Further, the radial profile of the diffuse reflectance pattern for each pixel is subject to changes which correlate with the depth of the absorber within the tissue. We suggest a detection geometry for the online measurement of these radial profiles, which can be realized by modifying a standard Scanning Laser Ophthalmoscope.
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