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Neurotransmitter Systems in Alcohol Dependence
Citation key Heinz2009
Author Heinz, A. and Beck, A. and Wrase, J. and Mohr, J. and Obermayer, K. and Gallinat, J. and Puls, I.
Pages 95 – 101
Year 2009
DOI 10.1055/s-0029-1214395
Journal Pharmacopsychiatry
Volume 42
Number S 01
Publisher Thieme
Abstract An interplay of different neurotransmitter systems has been implicated in the development and maintenance of alcohol dependence. Here we focus on neuroadaptations in reward-related neurotransmitter systems and their impact on central processing of alcohol-associated and reward-indicating stimuli. We discuss genotype effects on cue-induced neuronal activation and present new computational methods based on machine learning to deal with complex genotype-phenotype interactions, e.g. between brain atrophy and genes associated with glutamatergic and dopaminergic neurotransmission.
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